KMID : 0869220200240020069
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Journal of Korean Geriatric Psychiatry 2020 Volume.24 No. 2 p.69 ~ p.74
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Correlation between Sleep and C-reactive Protein of Patients in Amnestic Mild Cognitive Impairment and Alzheimer¡¯s Dementia
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Kim Ha-Yeon
Hong Seung-Chul Jeong Jong-Hyun Seo Ho-Jun Kim Tae-Won Kim Sung-Min Oh Ji-Hye Chung Jun-Soo Um Yoo-Hyun
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Abstract
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Objective: Sleep affects systemic inflammation and amyloid deposition, and sleep disturbance is known to be a risk factor for cognitive decline. To date, literatures on the relationship between peripheral inflammatory markers and sleep in Alzheimer¡¯s dementia and mild cognitive impairment patients have been scarce. The aim of this study was to determine the correlation between sleep and C-reactive protein (CRP) in Alzheimer¡¯s dementia and amnestic mild cognitive impairment patients.
Methods: A total of 81 patients were divided in to four groups: amyloid negative healthy control, amyloid negative amnestic mild cognitive impairment, amyloid positive amnestic mild cognitive impairment, and amyloid positive Alzheimer¡¯s dementia.
Demographic data and cognitive measurement through the Consortium to Establish a Registry for Alzheimer¡¯s Disease were conducted. Amyloid positivity status was attained through positron emission tomography scans using [18F]-flutemetamol. The quality of sleep was evaluated by the sleep item of Korean Neuropsychiatric Inventory (K-NPI-SLEEP), and peripheral blood tests were conducted to measure CRP.
Results: There was no statistically difference in CRP levels or K-NPI-SLEEP scores among four groups. Moreover, there was no association between K-NPI-SLEEP and CRP in four groups.
Conclusion: Since K-NPI-SLEEP score shows overall, subjective sleep problems, further follow-up studies in consideration for objective sleep studies to unravel the relationship of peripheral inflammatory markers and sleep in amnestic mild cognitive impairment and Alzheimer¡¯s dementia patients.
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KEYWORD
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Sleep, C-reactive protein, Alzheimer disease, Amyloid, Inflammation
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